ENHANCING THE SIGNAL-TO-NOISE RATIO AND GENERATING CONTRAST FOR CRYO-EM IMAGES WITH CONVOLUTIONAL NEURAL NETWORKS

Enhancing the signal-to-noise ratio and generating contrast for cryo-EM images with convolutional neural networks

In cryogenic electron microscopy (cryo-EM) of radiation-sensitive biological samples, both the signal-to-noise ratio (SNR) and the contrast of images are critically important in the image-processing pipeline.Classic methods improve low-frequency image contrast experimentally, by imaging with high defocus, or computationally, by applying various typ

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Mutation analysis of the NRXN1 gene in autism spectrum disorders

The aim of this study was to identify the sequence mutations in the Neurexin 1 (NRXN1) gene that has been considered as one of the strong candidate genes.A total of 30 children and adolescents (aged 3-18) with non syndromic autism were enrolled this study.Sequencing of the coding exons and the exon-intron boundaries of the NRXN1 gene was performed.

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